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Optoretinography: Past, Present and Future

Hosted By: Color Technical Group

27 September 2021, 13:00 - 14:00 - Eastern Daylight Time (UTC - 04:00)

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Optoretinography refers generally to the non-invasive, optical imaging of light-induced functional activity in the retina and draws a parallel to the classical electroretinogram. As a non-contact, all-optical probe of cellular-scale retinal function, it provides unprecedented access to the living eye, both in health and disease. While optical recordings of neural cells can be traced back more than 50 years ago, it is only very recently that the technology has evolved towards in vivo human translation.

In this webinar hosted by the Color Technical Group, Ramkumar Sabesan from the University of Washington will first provide a historical overview of probing neural activity with light. The webinar will then review the fundamental technological advances in retinal imaging that have led to the current state-of-the-art of optoretinography, including its application to color vision and clinical translation.  Finally, the challenges – technological, translational and mechanistic – that need to be overcome for widespread use and potential pathways of overcoming them will be discussed.

Subject Matter Level: Intermediate - Assumes basic knowledge of the topic

What You Will Learn:

  • Fundamentals of optical technologies that underlie optoretinography (ORG)
  • The underlying biophysical and physiological mechanisms of ORG
  • Applications of ORG to basic vision science and clinical research

Who Should Attend:

  • Trainees (undergraduate, graduate students and postdocs) interested in vision, optics and clinical science
  • Optical engineers/physicists
  • Vision scientists
  • Clinicians and clinician scientists


About the Presenter: Ramkumar Sabesan, University of Washington

Dr. Ramkumar Sabesan earned his Bachelor’s degree in Engineering Physics from the Indian Institute of Technology, Delhi and his Ph.D. in Optics at the Institute of Optics and Center for Visual Science at the University of Rochester. He did a postdoctoral fellowship at the School of Optometry at University of California, Berkeley studying the retinal basis of color perception using advanced high-resolution imaging, before joining the faculty at University of Washington Department of Ophthalmology. At UW, Dr. Sabesan holds adjunct appointments in the departments of Bioengineering and of Biological Structure, and is a member of the Graduate program in Neuroscience and University of Washington Institute for Neuroengineering. The Sabesan Lab’s basic vision science and translation research questions are centered around the ability of ophthalmic adaptive optics to provide in vivo cellular scale access to the visual system for physiological and psychophysical assays.