Microscopy Histopathology and Analytics

20 April 2020 – 23 April 2020 OSA Virtual Event - Eastern Daylight Time (UTC - 04:00)

Topics central to this meeting are novel forms of microscopies, computational modeling and algorithms, novel contrast agents, clinical analytics and translation to applications. Example applications areas are clinical diagnostics, surgical and non-surgical therapy guidance, prognostic procedures, high throughput drug screening and biomarker evaluation.


Topics

  1. Novel technology, devices, methods, models
    • Miniaturized devices
    • Endoscopic devices
    • Mobile phone-based microscopy
    • Multimodal microscopy
    • Multispectral microscopy
    • Computational microscopy
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  2. Machine learning and artificial intelligence
    • Computational modeling
    • Diagnostic, prognostic, and predictive algorithms
    • Data fusion and integration
    • Deep learning
    • Big data and cloud-based solutions
    • Image processing and analytics
    • Compressive and information-efficient sensing
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  3. Molecular microscopy and tissue preparation  
    • Quantitative approaches for pathology
    • Advances in devices and methods
    • Novel contrast agents, reporters, probes, molecules
    • Probe delivery and labeling methods
    • Optical clearing, tissue expansion
    • In situ hybridization, spatial transcriptomics, preservation of nucleic acids
    •  
  4. Challenges in translation
    • From bench to market
    • Standardization of designs and processes
    • Design of validation studies
    • Regulatory and reimbursement strategies
    • Understanding real world obstacles

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Speakers

  • Jennifer Dy, Northeastern UniversityUnited States
    Machine Learning for Optical Skin Microscopy: a Brief Tutorial, Challenges, and our Approach
  • David Entenberg, Albert Einstein College of MedicineUnited States
    Tracking the Fate of Disseminated Cancer Cells with Surgical Engineering, Intravital Imaging, and Correlative Microscopy
  • Peng Fei, Huazhong University of Sci and TechChina
    Deep-learning Light-field Microscopy for Three-dimensional Imaging of Highly Dynamic Biological Processes
  • Michael Giacomelli, University of RochesterUnited States
    Evaluation of Silicon Photomultiplier Technology for Laser Scanning Microscopy
  • Dina Kandil, Univ of Massachusetts Medical SchoolUnited States
    Translational Potential of Quantitative Fluorescence Polarization Imaging for Breast Cytopathology
  • Kivanc Kose, Memorial Sloan Kettering Cancer Center
    Detection of the DEJ and Segmentation of its Morphological Patterns in RCM Images of Melanocytic Skin Lesions
  • Tzu-Ming Liu, University of MacauMacau
    Visualizing Morphodynamics and Metabolic Status of Immune Microenvironment with Harmonic Generation and Multiphoton Fluorescence Microscopy
  • Yang Liu, University of PittsburghUnited States
    Visualizing Cancer Pathogenesis at the Nanoscale
  • Luciano Lucas, DRvision LLCUnited States
    AI for Microscopy Applications – The Era of Implementation
  • Victor Neel, Massachusetts General HospitalUnited States
    Clinical Applications of Polarized Light to Dermatologic Surgery
  • Inga Saknite, Vanderbilt University Medical CenterUnited States
    Post-transplant Leukocyte Motion in Human Skin Microvasculature by Noninvasive Reflectance Confocal Video Microscopy
  • Lingyan Shi, University of California San DiegoUnited States
    Visualizing Metabolic Activities in Cells and Animals with Optical Vibrational Imaging
  • Bryan Spring, Northeastern UniversityUnited States
    Development of Precision Photomedicine to Mop up Residual Tumor Deposits at the Surgical Margins
  • Willy Supatto, Ecole Polytechnique
    Advances in Fast Multiphoton Microscopy Using Light-sheet Illumination
  • Gracie Vargas, University of Texas at AustinUnited States
    Advancing Optical Biopsy Approaches in Oral Epithelial Neoplasia through Use of Combined Widefield Fluorescence and Multiphoton Autofluorescence Microscopy
  • Jesse Wilson, Colorado State UniversityUnited States
    Progress in Synthetic Multiphoton Contrast for in vivo Microscopy of Mucosal Melanoma

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Committee

  • Kevin Eliceiri, University of Wisconsin, United StatesChair
  • Milind Rajadhyaksha, Memorial Sloan Kettering Cancer Center, United StatesChair
  • Jonathan Liu, University of Washington, United StatesProgram Chair
  • Anna Yaroslavsky, University of Massachusetts Lowell, United StatesProgram Chair
  • Nada Boustany, Rutgers University, United States
  • Dana Brooks, Northeastern University
  • J. Quincy Brown, Tulane University, United States
  • David Dickensheets, Montana State University, United States
  • Charles DiMarzio, Northeastern University, United States
  • Marica Ericson, University of Gothenburg, Sweden
  • Sheng-Lung Huang, National Taiwan University, Taiwan
  • Nicusor Iftimia, Physical Sciences Inc., United States
  • Cecil Joseph, University of Massachusetts Lowell, United States
  • Florian Jug, Max-Planck-Inst Biophysikalische Chemie, Germany
  • DongKyun Kang, University of Arizona, United States
  • Irina Larina, Baylor College of Medicine, United States
  • Chi-Kuang Sun, National Taiwan University, Taiwan
  • Eric Tkaczyk, Vanderbilt University Medical Center, United States
  • Kevin Tsia, University of Hong Kong, Hong Kong
  • Alex Walsh, Texas A&M; University, United States

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Plenary Session

Steven LeBoeuf

Valencell, Inc, USA

Cuff-like Accuracy in Blood Pressure Monitoring via Wearable Photoplethysmography and Machine Learning

In this study, a machine learning model was developed to predict blood pressure(BP) based on optical and inertial sensor data collected from a commercially available photoplethysmography (PPG) sensor module embedded within a wearable device.

About the Speaker

Inventor of more than 80 granted patents and more than 100 patents pending in the field of wearable biomedical sensing, Steven LeBoeuf is one of the foundational innovators in wearable PPG sensors that are now embedded in millions of wearables on the market today. Before founding Valencell in 2006, Dr. LeBoeuf pioneered innovations in solid state materials, multiwavelength optoelectronic devices, high-power electronics, nanostructured materials and devices, and biochemical sensor systems while serving as a Senior Scientist and Biosensor Project Lead for General Electric. LeBoeuf has developed dozens of strategic partnerships with industry leading consumer technology brands, medical professionals, research institutions, medical device manufacturers, health and fitness companies, and start-ups. One of the most broadly quoted scientists and entrepreneurs in the field of wearable PPG sensing, LeBoeuf has served as a speaker in 50+ events around the world and is routinely interviewed by journalists, industry analysts, venture capitalists, and academic researchers. As a founding pioneer in modern wearables, LeBoeuf has managed Valencell’s foundational patent portfolio, which has been licensed to dozens of companies around the world and implemented in 40+ wearable devices, ranging from earbuds, hearing aids, wristbands, legbands, smartwatches, virtual reality systems, headbands and more. LeBoeuf holds a PhD in Electrical Engineering from North Carolina State University and BS degree in Electrical Engineering and Mathematics at Louisiana Tech University.

Catharine Young

SHEPHERD Foundation, USA

The Optics of a Changing Scientific Landscape

Based on the current pandemic, society will be forced to rethink how we operate on many levels and academia is no different. From graduate education, to policy reform to mentoring we now face an inflection point.

About the Speaker

Originally from South Africa, Dr. Catharine Young holds a doctorate degree in Biomedical Sciences and previously served as the Senior Director of Science Policy for the Biden Cancer Initiative. Here she fostered discussion and collaboration within the biotech, technology, science, and academic fields to drive innovation solutions and breakthroughs against cancer. Prior to this position, Catharine served as the Senior Science and Innovation Policy Advisor and Head of the DC team for the Foreign Ministry of the UK. Based at the British Embassy, Catharine influenced science and innovation policies of both the UK and US governments, industry, and academia. Following her Postdoctoral training at Cornell University in Biomedical Engineering, Catharine was selected as a AAAS Science and Technology Policy Fellow in the Office of the Assistant Secretary of Defense for Nuclear, Chemical, and Biological Defense Programs. Here she led international engagements on eliminating biological weapons, improving biosafety and biosecurity, and assisting in the DoD's response to the Ebola outbreak in Western Africa. Catharine also co-founded Blueprint International, a non-profit dedicated to providing novel technological solutions to some of the world’s most pressing social issues. Catharine is the Executive Director of the SHEPHERD Foundation. Recent awards include being selected as a TED Fellow, Alexandria 40 Under 40 and Social Enablers top 100 most inspiring social entrepreneurs. Catharine is an advocate for women in STEM and has been a contributor to major social and media networks including TED-Ed, the Guardian and the UK Science and Innovation Network.

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