Optics and the Brain

Optics and the Brain

The recent BRAIN initiative in the USA, and the Human Brain Project in Europe have highlighted how little we know about the way that the brain works. These initiatives have identified that technologies are urgently needed to better probe the working brain, across all levels from single neurons to entire behaving organisms. Optical tools and techniques have become central to neuroscience and biomedical research, spanning from optogenetics and fluorescent proteins, to in-vivo microscopy and approaches for human brain imaging. This conference will bring together researchers working in all aspects of optics in the brain and will serve as a forum for discussion of existing and emerging techniques as well as future directions that could be envisaged to shed new light on the healthy and diseased brain.

  1. Optics in the Human brain
    • Diffuse optical tomography (DOT)
    • Functional near infrared spectroscopy (fNIRS)
    • Diffuse Correlation spectroscopy (DCS)
    • Neurophotonic biopsy
    • Photodynamic therapy
    • Intrasurgical optical imaging
    • Fast Optical Signals
    • Clinical translation
  2. Structural and multiscale brain imaging
    • OCT for structural imaging in the CNS
    • 2nd- and 3rd- harmonic structural imaging
    • Deep phase contrast for neuroanatomy
    • Single particle tracking for synapse investigation
    • Superresolution imaging in the CNS
    • Whole brain neuro-anatomy with light sheet microscopy
    • Whole brain neuro-anatomy with
  3. Functional brain microscopy techniques
    • In vivo Multi-photon functional imaging
    • Deep Multi-photon imaging
    • High-speed / multiplexing functional microscopy techniques
    • Functional light-sheet imaging
    • Light-field imaging
    • Temporal focusing microscopy
    • Wearable / implantable microscopes
    • Adaptive optics approaches to imaging
  4. Functional brain macroscopy and hybrid techniques
    • Wide-field VSD / Calcium imaging
    • Speckle flow imaging
    • Optical intrinsic signal imaging
    • Opto/Photoacoustic imaging of the CNS
    • Functional OCT in the CNS
    • Implantable devices and probes for imaging and recording
  5. Optogenetics and optical modulation tools and techniques
    • Multispectral and hybrid optogenetic approaches
    • Adaptive optics for beam shaping
    • Tools for targeted optogenetic light delivery
    • Optical dissection of brain function with caged compounds
    • Infrared Neural Stimulation,
    • Photo-coagulation and targeted photodamage
    • Laser axotomy in vivo
    • Optical Cochlear prostheses
    • Single Synapse stimulation
    • Interconnections between the neurobiological and the opto/electrical devices
    • Towards optogenetics in humans
  6. Novel contrast and genetic approaches for brain imaging and modulation
    • Fluorescent proteins to image structure
    • Fluorescent proteins to image function / metabolism
    • Optogenetic tools for photoactivation and multiplexing
    • Raman-based contrast for brain imaging
    • Voltage sensitive dyes
    • Vascular tracers
    • Phosphorescent probes
    • Cerenkov imaging
    • Multi-modality contrast
    • Probes for CNS disease

Eric Betzig, Janelia Research Campus, Howard Hughes Medical Institute, USAImaging Life at High Spatiotemporal Resolution, Plenary
Nobel Prize Winner in Chemistry 2014

Tayyaba Hasan, Harvard Medical School, Massachusetts General Hospital, USAPhotodynamic Therapy (PDT): A Photochemical Slice of Clinical Biophotonics, Plenary

W.E. Moerner, Stanford Univ., USAPupil Plane Modulation to Extract Information from Single-Molecule Emitters for Super-Resolution Microscopy, Plenary
Nobel Prize Winner in Chemistry 2014

Polina Anikeeva, Massachusetts Institute of TechnologyUnited StatesOptoelectronic Probing of Neural Circuits with Multifunctional Fibers, Invited

Markus Axer, Forschungszentrum Jülich GmbHTowards a High-resolution Fiber Model of the Human Brain with 3D Polarized Light Imaging, Invited

Robert Campbell, University of AlbertaCanadaEngineering the Next Generation of Optogenetic Reporters to Illuminate Neuronal Activity, Invited

Lawrence Cohen, Yale UniversityUnited StatesGenetically Encoded Fluorescent Voltage Indicators (GEVIs) in the Mammalian Brain, Invited

Joseph Culver, Washington University in St LouisUnited StatesOptical Imaging of Functional Connectivity, Invited

Vincent Ricardo Daria, Australian National UniversityAustraliaLight-neuron Interactions: Key to Understanding the Brain, Invited

Viviana Gradinaru, California Institute of TechnologyUnited StatesVisualizing the Activity and Anatomy of Brain Circuits: Optogenetic Sensors and Tissue Clearing Approaches, Invited

Enrico Gratton, University of California IrvineUnited States3D Orbital Tracking for Super-resolving the Dynamics of Gene Expression, Invited

Fritjof Helmchen, University of ZurichSwitzerlandIn Vivo Calcium Imaging of Information Processing in Mouse Neocortex during Behavior, Invited

Timothy Holy, Washington University in St LouisUnited StatesLabel-free Imaging in Deep Tissue at Cellular Resolution, Invited

David Kleinfeld, University of California, San DiegoUnited StatesBlood Flow, Brain Vascular Dynamics, and the Basis of Resting State fMRI, Invited

Frederic Leblond, Polytechnique MontrealCanadaOptical Spectroscopy and Molecular Detection Technologies to Guide Neurosurgical Interventions, Invited

Jerome Lecoq, Stanford UniversityUnited StatesVisualizing Mammalian Brain Area Interactions by Dual-axis Two-photon Calcium Imaging, Invited

Michael Lin, Stanford UniversityUnited StatesVisualizing Electrical Activity in Neural Systems Using a New Family of Fast Genetically Encoded Voltage Indicators, Invited

Wei Min, Columbia UniversityUnited StatesSeeing Molecular Vibrations: Optical Imaging of Small Molecules for Biomedicine, Invited

Timothy Murphy, University of British ColumbiaUnited StatesPoint-source Maps: Relations between Mesoscopic Imaging of Mouse Cortex and Neuronal Spiking, Invited

Francesco Pavone, European Lab for Non-Linear SpectroscopyItalyIntroduction to Neurophotonics, Invited

Leonardo Sacconi, European Lab for Non-Linear SpectroscopyItalyTowards a Comprehensive Understanding of Brain Structure by Correlative Microscopy, Invited

Shy Shoham, Technion Israel Institute of TechnologyIsraelPhotonic Interfacing with Large Scale Natural and Bioengineered Neuronal Networks, Invited

Peter So, Massachusetts Institute of TechnologyUnited StatesFrontiers in Neurobiological Imaging: Scale, Speed, and Sensitivity, Invited

Alipasha Vaziri, Universitat WienAustriaWhole-brain Dynamic Map of Neuronal Circuit, Invited

Cathie Ventalon, Ecole Normale SupérieureFranceA Fiberscope of Spatially Selective Photoactivation and Functional Fluorescence Imaging in Freely Behaving Mice, Invited

Bruno Weber, Universitat ZurichSwitzerlandIn Vivo Two-Photon Imaging of Energy Metabolism at Single Cell Level using Genetically Encoded Sensor, Invited

Junjie Yao, Washington University in St LouisUnited StatesPhotoacoustic Tomography Beats Optical Diffusion, Invited

General Chairs
Elizabeth Hillman, Columbia Univ., USA
Francesco Pavone, European Lab for Non-Linear Spectroscopy, Italy

Program Committee
Katrin Amunts, Forschungszentrum Julich GmbH, Germany
Lawrence Cohen, Yale Univ., USA
Fritjof Helmchen, Univ. of Zurich, Switzerland
Timothy Holy, Washington Univ. in St Louis, USA
Thomas Knopfel, Riken Brain Science Institute, Japan
Frederic Leblond, Polytechnique Montreal, Canada
Qingming Luo, Huazhong, Univ. of Science and Technology, China
Anita Mahadevan-Jansen, Vanderbilt Univ., USA
Tim Murphy, Univ. of British Columbia, Canada
Darcy Peterka, Columbia Univ., USA
Shy Shoham, Technion Israel Institute of Technology, Israel
Changhuei Yang, California Institute of Technology, USA

Conference Plenary Session

Monday, 13 April, 08:00 – 10:00

Eric Betzig, Janelia Research Campus, Howard Hughes Medical Institute, USA
Tayyaba Hasan, Harvard Medical School, Massachusetts General Hospital, USA
W.E. Moerner, Stanford Univ., USA

Conference Reception

Monday, 13 April, 18:30 – 20:00
Join your fellow attendees for the Congress Reception. Enjoy delectable fare while networking. The reception is open to committee/presenting author/student and full conference attendees. Conference attendees may purchase extra tickets for their guest.

Industry Program
Tuesday, 14 April 10:30 - 13:30

Making the Connection between Biomedical Industry Products and Current Research in Optics and Photonics
Keynote Session

Eric Buckland, CEO, Bioptigen, USA

Panel Session

Panelists from the academic, industrial, financial and agency funding world will discuss the challenges that exist when taking scientific knowledge from the bench-top to the patient-side. From success stories, and some misadventures, we will learn from the panelist the best practices to commercializing the research presented at the conference. Funding issues in the start-up phase may be discussed; regulatory hurdles along the way examined; recovery from missteps reviewed; even challenges once a company matures and is ripe for its leaders to begin the exit process may be pondered. Bring questions and expect a highly interactive session with those who have ventured down this road.

Brian Wilson, Senior Scientist, University Health Network, Canada

Participating panelists:
Eric Buckland, CEO, Bioptigen, USA
Lindsay Machan, Associate Professor, Dept. of Radiology, Univ. of British Columbia, Canada
Brian Pogue, Professor, Engineering Science, Dartmouth College, USA; President, DoseOptics, LLC, USA
Edmund Talley, Program Director, National Inst. of Neurological Disorders and Stroke, USA
Adam Wax, Theodore Kennedy Professor, Duke University, USA; Founder and Chairman of Oncoscope, Inc., USA

Bright Ideas Pitch Panel Luncheon

Sponsored by: Hamamatsu

Invitation to Present Your New Technology and Innovative Ideas to Entrepreneurs & Venture Capitalists

Do you have a startup or an idea for a new company? Present your technology, explain why it’s valuable and discuss the next steps to commercialization.

This is a unique opportunity to present and collaborate with entrepreneurs and venture capital panelists about your emerging company and/or new technologies that may offer solutions to the challenges faced by professionals in the life sciences.

Share your dream and receive valuable direction from those that have experienced the excitement and trepidation of starting a photonics business.

Get both immediate market and investor feedback during the “OSA Bright Ideas Luncheon” by presenting your idea to the Entrepreneur and VC Panel.

Our panel of experts will give you their advice on what you need to do to launch a new company or take your startup to the next level.

In return for your brief presentation you will get the benefit of our panel’s decades of experience in commercializing photonics. 5-minute presentations will be followed by comments and suggestions from our panel of experts.

Industry Program Committee

Alain Villeneuve, President, Optav Solutions Inc., Canada
Alex Fong, Senior VP, Life Sciences and Instrumentation, Gooch and Housego, USA
Tom Haslett, CTO, Avo Photonics, USA
Ken Kaufmann, Marketing Director, Hamamatsu Corp., USA

Joint Poster Session

Tuesday, 14 April, 15:30 – 16:30
Posters are an integral part of the technical program and offer a unique networking opportunity, where presenters can discuss their results one-to-one with interested parties. Each author is provided with a board on which to display the summary and results of his or her paper.

Eric Betzig

Janelia Research Campus, Howard Hughes Medical Institute, USA

Nobel Prize Winner in Chemistry 2014

Imaging Life at High Spatiotemporal Resolution
I will describe three different technologies that balance the inevitable tradeoffs of spatial resolution, speed, and non-invasiveness in fluorescence microscopy: 3D localization microscopy of cellular ultrastructure; nonlinear structured illumination microscopy of live cell dynamics in the sub-100 nm regime; and lattice light sheet microscopy of rapid 3D dynamic processes in vivo.

Tayyaba Hasan

Harvard Medical School, Massachusetts General Hospital, USA

Photodynamic Therapy (PDT): A Photochemical Slice of Clinical Biophotonics
This presentation will focus on the challenges associated with applying PDT as a theranostic modality for complex disease. Intricacies associated with formulation and drug delivery, dosimetry, and combination therapies that address cancer-sustaining pathways will be discussed.

W.E. Moerner

Stanford University, USA

Nobel Prize Winner in Chemistry 2014

Pupil Plane Modulation to Extract Information from Single-Molecule Emitters for Super-Resolution Microscopy
Single-molecule imaging and active control of concentration lead to super-resolution microscopy for various applications.   Pupil plane phase modulation is a powerful tool to maximize information about 3D position, orientation, and other properties of the nanoscale emitters.