Biomedical Optics (BIOMED)

Biomedical Optics (BIOMED)

The 2014 OSA BIOMED meeting took place 26 - 30 April in Miami, FL, USA. For information about future BIOMED meetings, email

There are few biological science studies that are not touched by biomedical optics and the number of medical applications of biomedical optics continues to grow at a rampant pace. Optical methods play a critical role in biotechnologies ranging from genomics to cytomics to in vitro and in vivo diagnostics and to in vivo imaging and therapies. Biophotonics technologies are being translated into medical diagnostics and open up new frontiers of fundamental biology. The upcoming Biomedical Optics meeting covers the diversity of cutting edge research and brings together leading scientists, engineers, biologists, and physicians engaged in biological and medical research using optical methods. With over 400 attendees, this must-attend meeting affords the exceptional opportunity for one-on-one interactions with leaders in the field allowing for lively discussions of the latest research.

Biomedical Optics (BIOMED) is designed to address the forefront R&D areas in the biomedical sciences ranging from molecular level progress in our understanding of bio-processes, to new and improved advances in instrumentation, to state-of-the-art techniques to diagnose and treat diseases. At the molecular level, novel nano-photonic and other currently developed optical molecular probes will be described and applications to quantify structural and functional parameters and to diagnose cellular and medical conditions. The recent advances and the effectiveness of single and multi-modality probes and imaging to determine structure, perfusion, drug delivery, cellular pathology, etc. will be presented. Research and applications utilizing bio-markers to determine cell structure and function, disease boundaries, drug delivery effectiveness, etc. will be discussed in detail as well as the latest progress in other widely used optical techniques including optical microscopy, photo-acoustic imaging, optical coherence tomography, and optical spectroscopy. Advances in therapies using optical techniques and their relative effectiveness will be examined.  Finally, the important investigations of the latest optical imaging and tomography as well as the technology to implement these imaging studies will be outlined. As examples, studies using diffuse optical imaging, fluorescence, correlation, multi-spectral imaging etc. will be covered and their application to such areas as functional and transport imaging in vivo and clinical diagnostic applications. BIOMED offers an exceptional opportunity to learn the latest results in the field of biomedical optics and provides an attendee the opportunity to discuss biomedical science and applications with the world leaders in this area.

Topic Categories

BIO 1: Biophysics, Biology and Biophotonics: the Crossroads
B3C addresses biophotonics at the forefront of biology and biophysics including the areas where optical techniques may find future applications as well as the biological principles of light-tissue interactions.

  • Optogenetics

  • Neurophotonics

  • Optics in genomics and epigenomics

  • Optics and cancer microenvironment

  • Biological principles of optical diagnostic and therapeutic technologies

  • Optical molecular biophysics

  • Cytomics

BIO 2: BioNanophotonic and Molecular Probes

  • Novel Molecular and Functional Contrast Agents

  • Metal Nanoparticles

  • Quantum Dots

  • Upconverting Nanoparticles

  • Inorganic/Organic Hybrid Materials

  • Surface Enhanced Raman Scattering and Surface Enhanced Fluorescence

  • Single Molecule Techniques

  • In vitro and in vivo Applications of Molecular and Functional Imaging

  • Photodynamic Therapy

BIO 3: Optical Microscopy: Techniques and Applications

  • Microscopy in vivo

  • Spectrally- and Temporally-Resolved Microscopy

  • Multiphoton/Nonlinear Microscopy

  • Super Resolution Microscopy

  • Raman-Scattering based Microscopy

  • Novel Forms of Microscopy

  • Endoscopic Microscopy

  • Multimodal Microscopy

  • In vivo Applications and Clinical Translation

BIO 4: Photoacoustic Imaging and Spectroscopy

  • Photoacoustic Tomography

  • Photoacoustic Microscopy

  • Functional Photoacoustic Imaging

  • Ultrasound Modulated Optical Imaging

  • Photoacoustic Endoscopy

  • Multimodal Photoacoustic Imaging

  • Photoacoustic Molecular Imaging

  • Photoacuostic Theory and Modeling

  • In vivo and Clinical Applications of Photoacoustic Techniques

BIO 5: Optical Coherence Tomography with Applications

  • OCT Technology Development Spectroscopic OCT

  • OCT Light Source Development

  • Ultrahigh Resolution and Ultrahigh Speed OCT

  • Functional OCT (Doppler, Polarization Sensitive and Others)

  • Contrast Enhancement Techniques in OCT

  • Optical Coherence Microscopy

  • Phase Sensitive OCT Technology

  • Multimodal Techniques

  • OCT Theory and Modeling

  • Image Processing and Segmentation

  • Biomedical and Clinical Applications of OCT

BIO 6: Optical Imaging and Tomography with Applications

  • Diffuse Imaging and Spectroscopy: Clinical and in vivo Applications

  • Instrumentation for Diffuse Optical Imaging

  • Theoretical Methods and Image Reconstruction for Optical Tomography

  • Diffuse Fluorescence Tomography

  • Fluorescence Lifetime Tomography and Imaging

  • Diffuse Correlation Spectroscopy

  • Transport-Regime Modeling and Imaging

  • Optical Imaging within Multimodal Neuroimaging

  • Functional Imaging Techniques in Neuroscience

  • Multi-Spectral Imaging

BIO 7: Optical Spectroscopy with Applications

  • Fluorescence Spectroscopy and Imaging

  • Reflectance Spectroscopy and Imaging

  • Mie Scattering Spectroscopy and Imaging

  • Light Subdiffusion and Diffusion in Tissue

  • Light Scattering in Tissue

  • Low-coherence Interferometry and Spectroscopy

  • Depth-sensitive Spectroscopy

  • Polarization Spectroscopy

  • Raman Spectroscopy and Imaging

  • Multi-Modal Spectroscopy and Imaging

  • Multi-Spectral Imaging

  • In vivo and Clinical Applications of Optical Spectroscopy

Kishan Dholakia, University of St Andrews, United Kingdom, Shaping Light for Imaging, Manipulation and Transfection, Plenary

Xingde Li, Johns Hopkins University, United States, Label-free Nonlinear Endomicroscopy Imaging of Tissue Histology in vivo, Plenary

Lev Perelman, Harvard University, United States, Biomedical Imaging and Spectroscopy with Scattered Light, Plenary

Peter So, Massachusetts Institute of Technology, United States, High Throughput, High Content Image Informatics Based on Structured-light Microscopy, Plenary

Adam Wax, Duke University, United States, Multispectral Multiple Scattering Low Coherence Interferometry for Tissue Diagnostics, Plenary

Randy Bartels, Colorado State University, United States, Spatial-frequency-modulated Imaging , Invited

Paul Beard, University College London, United Kingdom, Title to be Announced, Invited

Joerg Bewersdorf, Yale University , United States, Live-cell video-rate Single-molecule Switching Nanoscopy , Invited

Claude Boccara, ESPCI, France, Low Coherence Interferometry as a Diagnosis Tool , Invited

Hugh Byrne, DIT Focas Institute, Ireland, Vibrational Spectroscopy: Disease Diagnostics and Beyond, Invited

Victor Chernomordik, National Institutes of Health, United States, Near-Infrared Fluorescence Imaging for In Vivo Assessment of HER2 Receptor Density in HER2-positive Tumors , Invited

David Cuccia, Modulated Imaging Inc, United States, Title to be Announced, Invited

Hamid Dehghani, University of Birmingham, United Kingdom, Computational Developments for Near Infrared Spectroscopic Tomography , Invited

Jinming Gao, UT Southwestern Medical Center at Dallas, United States, Title to be Announced , Invited

Jin Kang, Johns Hopkins University, United States, Optical Coherence Tomography Guided Smart Microsurgical Tools, Invited

Anand Kumar, Harvard University, United States, Molecular Imaging Using Time Domain Fluorescence, Invited

Theo Lasser, Ecole Polytechnique Federale de Lausanne, Switzerland, Optical Coherence Microscopy: From Tissue to Cell , Invited

Charles Lin, Massachusetts General Hospital, United States, Optical Techniques for Studying Bone Regeneration and Bone Marrow Transplantation, Invited

Wei Min, Columbia University, United States, Bioorthogonal Chemical Imaging for Biomedicine, Invited

Thomas Nobis, Carl Zeiss AG, Germany, Invited

Vasilis Ntziachristos, Technische Universität Munchen, Germany, Optical Imaging Redefined: Advances in Multispectral Optoacoustic Tomography (MSOT), Invited

Thomas Perkins, University of Colorado at Boulder JILA, United States, Title to be Announced , Invited

Jessica Ramella-Roman, Florida International University, United States, Assessment of the Natural History of Treated and Untreated Scars with a Novel Imaging System, Invited

Jianghong Rao, Stanford University, United States, Semiconducting Polymer Nanoparticles as the Nanoplatform to Design Nanoprobes for Molecular Imaging , Invited

Igal Szleifer, Northwestern University, United States, Macromolecular Crowding as a Regulator of Transcription , Invited

Gijs van Soest, Thoraxcenter Erasmus MC, Netherlands, Heartbeat OCT , Invited

Martin Villiger, Wellman Center for Photomedicine, United States, Intravascular Polarization Sensitive Optical Coherence Tomography , Invited

Fabrice Wallois, GRAMFC, France, At the Very Onset of Language Network : A Combined Electrical and Optical Imaging (HD-EEG/fNIRS) Approach in Early Premies, Invited

Lihong Wang, Washington University in St Louis, United States, Photoacoustic Tomography: Beat Optical Diffusion and Diffraction, Invited

Bengang Xing, Nanyang Technological University, Singapore, NIR Light Mediated Upconversion Platforms for Localized Imaging and Controlled Activation of Payload Molecules, Invited

Changhuei Yang, California Institute of Technology, United States, Fourier Pytchographic Microscopy, Invited

General Chairs

Vadim Backman, Northwestern Univ., USA
Stefan Andersson-Engels, Lund Univ., Sweden

Vice Chairs

Stephen Boppart, Univ. of Illinois at Urbana-Champaign, USA
Christoph Hitzenberger, Medizinische Universität Wien, Austria

Program Committee

BIO 1: Biophysics, Biology and Biophotonics: The Crossroads

Nada Boustany, Rutgers University, USA, Subcommittee Chair
Elizabeth Hillman, Columbia University, USA, Subcommittee Chair
Halina Rubinsztein-Dunlop, University of Queensland, Australia, Subcommittee Chair
Michael Berns, University of California, Irvine, USA
Ed Boyden, MIT, USA
Kevin Chalut, University of Cambridge, UK
Alberto Diaspro, Instituto italiano di Tecnologia, Italy
Irene Georgakoudi, Tufts University, USA
Richard M. Levenson, University of Califorina, Davis, USA
Judy R. Mourant, Los Alamos National Laboratory, USA
Nozomi Nishimura, Cornell University, USA

BIO 2: BioNanophotonic and Molecular Probes

Gregory Faris, SRI International, USA, Subcommittee Chair
Gang Zheng, University of Toronto, Canada, Subcommittee Chair
Walter Akers, Washington University School of Medicine, USA
Daniel Chiu, University of Washington, USA
Jason McCarthy, Harvard Medical School, USA
Andrew Tsourkas, University of Pennsylvania, USA
Yasuteru Urano, University of Tokyo, Japan
Adam Wax, Duke University, USA

BIO 3: Optical Microscopy: Techniques and Applciations

Adela Ben-Yakar, University of Texas, Austin, USA, Subcommittee Chair
Paul Campagnola, University of Wisconsin, Madison, USA, Subcommittee Chair
Yang Liu, University of Pittsburgh, USA, Subcommittee Chair
Randy A. Bartels, Colorado State University, USA
Nicholas J. Durr, MIT, USA
Jeremy D. Rogers, University of Wisconsin-Madison, USA
Guoan Zheng, University of Connecticut, USA

BIO 4: Photoacoustic Imaging and Spectroscopy

Lihong Wang, Washington University, USA, Subcommittee Chair
Daniel  Razansky, Technische Universitat Munchen, Germany, Subcommittee Chair
Hao Zhang, Northwestern University, USA, Subcommittee Chair
Paul C. Beard, University College London, UK
Stanislav Emalianov, University of Texas at Austin, USA
Martin Frenz, Universitat Bern, Switzerland
Pai-Chi Li, National Taiwan University, Taiwan
Alexander Oraevsky, Fairway Medical Technologies, Inc., USA
Guenterh Paltauf, Karl-Franzens-Universitat Graz, Austria
Daniel Razansky, Helmholtz Zentrum München GmbH, Germany
Wiendelt Steenbergen, Universiteit Twente/MIRA Institute, Netherlands
Jun Zou, Texas Agricultural and Mechanical University, USA

BIO 5: Optical Coherence Tomography with Applications

Xingde Li, Johns Hopkins University, USA, Subcommittee Chair
David Sampson, University of Western Australia, Australia, Subcommittee Chair
Yoshiaki Yasuno, University of Tsukuba, Japan, Subcommittee Chair
Yu Chen, University of Maryland, USA
Zhongping Chen, University of California - Irvine, USA
James G. Fujimoto, MIT, USA
Kirill Larin, University of Houston, USA
Rainer Leitgeb, Medical University of Vienna, Austria
Amy Oldenburg, University of North Carolina at Chapel Hill, USA
Melissa Suter, MGH, Harvard Medical School
CC (Chih-Chung) Yang, National University of Taiwan
Maciej Wojtkowski, Nicolaus Copernicus University, Poland

BIO 6: Optical Imaging and Tomography with Applications

Hamid Dehghani, University of Birmingham, UK, Subcommittee Chair
Maria Angela Franceschini, Harvard Medical School, USA, Subcommittee Chair
Brian Pogue, Dartmouth College, USA, Subcommittee Chair
Randall L. Barbour, SUNY Downstate Medical Center, USA
David Cuccia, Modulated Imaging, USA
Stefan Carp, Massachusetts General Hospital, USA
Jeremy C. Hebden, Univ. College London, UK
Huabei Jiang, Univ. of Florida, USA
Adam Liebert, Nalecz Inst. of Biocybernetics and Biomedical Engineering, Warsaw, Poland
Hanli Liu, University of Texas at Arlington, USA
Mark Niedre, Northeastern University, USA
Eiji Okada, Keio Univ., Japan
Antonio Pifferi, Politecnico di Milano, Italy
Ilya Turchin, Inst. of Applied Physics, Russia
Arjun Yodh, Univ. of Pennsylvania, USA
Quing Zhu, Univ. of Connecticut, USA

BIO 7: Optical Spectoscopy with Applications

Young Kim, Purdue University, USA, Subcommittee Chair
Martin Leahy, NUI Galway, Ireland, Subcommittee Chair
Igor Meglinski, University of Otago, New Zealand, Subcommittee Chair
Sergey Alexandrov, National University of Ireland, Ireland
Hrebesh Subhash,

Industry Program Committee

Kelly Gregorak, Boulder Nonlinear Systems, Inc., USA
Alain Villeneuve, Genia Photonics, Canada
Rob Morris, Ocean Optics, Inc., USA
Tom Haslett, Avo Photonics, USA
Vadim Backman, Northwestern University, USA, Liaison to the General Committee

NIRFAST Pre-conference Workshop

Pre-Conference 2-day Training
25-26 April 2014, Miami Hilton Downtown

This workshop provides hands-on instruction with Nirfast, a MATLAB based package for modeling Near-Infrared light transport in tissue. This workshop will be held prior to the Biomedical Optics Topical meeting and will cover basic aspects of Nirfast including the following:

  •     DICOM image segmentation to create 2D and 3D finite element models which match experimental tissue volumes
  •     Modeling forward propagation of diffuse light in tissue
  •     Calculating inverse problems to recover diffuse tomography images
  •     Visualization of solutions with and without DICOMs
  •     Spectroscopic imaging using multiple wavelengths of light
  •     Emission tomography for fluorescence molecular imaging or bioluminescence tomography

No prior Nirfast experience is needed, although participants are encouraged to download the code and install it prior to the workshop. Participation requires the use of your own laptop computer installed with Matlab 2009a or newer (or a demo installation for temporary use), on a 64-bit Windows or 64-bit Mac laptop. Basic knowledge of Matlab is recommended.

There is no registration fee to attend the workshop but an application is required.  For more information on the Nirfast workshop or to register visit the website

Poster Sessions
Sunday, 27 April; Monday, 28 April; Tuesday, 29 April, 13:30 - 15:00
Exhibit Hall
Posters are an integral part of the technical program and offer a unique networking opportunity, where presenters can discuss their results one-to-one with interested parties. Each author is provided with a board on which to display the summary and results of his or her paper.
Postdeadline Papers
Sunday, 27 April, 19:00 - 20:30
The BioMed committee will accept a limited number of postdeadline papers for oral presentation.  

Conference Reception
Monday, 28 April, 17:30 - 18:30
Exhibit Hall

Join your fellow attendees at the conference reception. Enjoy delectable fare while networking. The reception is open to full congress attendees. Conference attendees may purchase extra tickets for their guest.

Industry Keynote
Tuesday, 29 April, 8:00 - 9:30

Industry Panel Discussion: “Translational Research: Evolution from Bench to Bedside”
Tuesday, 29 April, 10:00 - 12:00


Mahlega Hassanpour, Washington University in St. Louis School of Medicine, USA - Imaging speech comprehension in quiet with high density diffuse optical tomography (BM3A.5)
Carmen Kut, Johns Hopkins School of Medicine, USA - SS-OCT Imaging and Optical Property Mapping for Intro-operative Guidance of Brain Tumor Surgery (BT3A.63)
Andy K.S. Lau, University of Hong Kong, Hong Kong - Quantitative phase asymmetric-detection time-stretch optical microscopy (Q-ATOM) for ultrafast cellular imaging (BT3A.4)
Fredrick South, University of Illinois at Urbana-Champaign, USA - Differentiation of Ex Vivo Human Breast Tissue using Polarization Sensitive Optical Coherence Tomography (BT3A.71)


Gemma Bale, University College London, UK - In-Vivo Measurements of Cerebral Changes in Cytochrome-c-Oxidase using Broadband Near-Infrared Spectroscopy in Perinatal Hypoxic-Ischaemic Encephalopathy (BS3A.39)
Will Eldridge, Duke University, USA - Fast Wide-field Photothermal Optical Lock-in Imaging of Gold Nanospheres to Provide Molecular Contrast in Quantitative Phase Imaging (BT3A.49)
Gerrit Held, University of Bern, Germany - Influence of illumination position on image contrast in epi-optoacoustic imaging of human volunteers (BS3A.75)
Rajesh Kanawade, Clinical Photonics Lab, Erlangen Graduate School in Advanced Optical Technologies (SAOT), Germany - Photoplethysmography (PPG) Sensor for Real-time Body Hemodynamics Monitoring - An Efficient, Robust and Simple Approach for Clinical Shock Diagnostics (BS3A.19)
Lei Li, Washington University in St. Louis, USA - Fully motorized optical-resolution photoacoustic microscopy (BS3A.69)
Mohammad Naser, Rutgers University, USA - Quantification of Bax/Bak-Dependent Morphological Changes by Textural Analysis of Optical Scatter Images (BT3A.37)
Kenneth Ng, University Health Network, University of Toronto, Canada - Determination of Porphysome Nanovesicle Structural Fate Using Förster Resonance Energy Transfer (BT3A.50)
Rachel Schafer, University of Arizona, USA - Multi-Modality Imaging in a Mammary Window Chamber Mouse Model (BT3A.41)
Qiqi Sun, Hong Kong University of Science and Technology, Hong Kong - Advanced nonlinear optical microscopy for imaging of development of skeletal muscle (BT3A.15)
Patrick Wright, Washington University in St Louis, USA - Spontaneous FAD Dynamics Reveal Functional Connectivity Patterns In Mice (BM3A.4)