Spatially Precise Optogenetics at Depth Incubator Meeting
Cracking Neural Circuits with Structured Illumination & Ultrafast Imaging in the Intact Brain
8-10 December 2013 ● OSA Headquarters ● Washington, D.C.
HOSTS: Hillel Adesnik, University of California, Berkeley, United States
Shy Shoham, Technion - Israel Institute of Technology, Israel
Laura Waller, University of California, Berkeley, United States
Although optogenetics is revolutionizing how neuroscientists investigate nervous system function, few studies have taken advantage of precise spatial illumination to manipulate neural activity at the resolution of single cells or local microcircuits. Advances in multi-photon structured illumination, ultrafast imaging and micron scale light sources promise to open up a whole new field of investigation into the basic operation of neural circuits. This Incubator Meeting will focus on the development of optical approaches that will radically improve the spatial and temporal resolution with which we can manipulate and monitor neural activity optogenetically.
The goal of the meeting is to bring together neuroscientists, engineers, and industry representatives that would not normally interact but are nevertheless experts in structured illumination, high-speed multi-photon imaging, optogenetic investigation of neural circuits, and computational optical approaches. With a major goal of the BRAIN Initiative to comprehensively image and manipulate neural activity on a massive scale but with cellular resolution, participants of this meeting will not only present their recent advances, but also discuss the major outstanding challenges in this field and how to surmount these challenges to develop the necessary technologies that will unlock fundamental aspects of brain function and disease.
Scope and Featured Topics
Optogenetics – sensitizing neurons to light genetically – is rapidly altering how scientists reveal the basic operation of the brain circuits that are central to sensation, action, and cognition. The vast majority of optogenetic studies to date have primarily capitalized on the genetic side of optogenetics taking advantage of the specificity of gene expression to control and image unique cell types and connections in the brain. However, precise spatial control of the illuminating light affords an additional dimension of specificity that has been underutilized, partly owing to the challenges posed by the scattering properties of brain tissue. Recent and future work in multi-photon imaging and structured illumination, combined with alternative approaches – such as micron scale, implantable illumination devices – promise to open up whole new avenues of research to understand the elementary basis of neural computation, sensory coding, and neural defects in brain diseases such as autism, schizophrenia, epilepsy, and other disorders.
Three main focus areas for this meeting will be to:
Structured illumination to optogenetically control neural activity precisely in space and time
Ultrafast imaging to reconstruct patterns of neural activity with millisecond precision in large volumes of brain tissue
Local implantable illumination devices, to control neural activity at brain depths beyond the limits of multi-photon microscopy
Meeting Schedule [check back for full agenda]
Sunday, 8 December
Participant Welcome Dinner
Monday, 9 December
8:00 am Breakfast
8:30 am Program begins, lunch is included
6:30 pm Participant Dinner
Tuesday, 10 December
8:00 am Breakfast
8:30 am Program begins, lunch is included
4:00 pm Program ends [may end earlier, full agenda will be available shortly]
Attendees [as of 11-22-13]
Hillel Adesnik, University of California, Berkley, USA; Marco Arrigoni, Coherent Inc., USA; Thomas Bifano, Boston University, USA; Serena Bovetti, Italian Institute of Technology, Italy; James Cotton, Baylor College of Medicine, USA; Marcus Dantus, Michigan State University, USA; Shyamsunder Erramilli, Boston University, USA; Elizabeth Hillman, Columbia University, USA; Prem Kumar, Defense Advanced Research Projects Agency, USA; Rich Lepkowicz, Defense Advanced Research Projects Agency, USA; Guoqiang Li, Ohio State, USA; Keith Mathieson, University of Strathclyde, United Kingdom; Jordan McCall, Washington University School of Medicine, USA; Jerome Mertz, Boston University, USA; Darwin Palima, DTU Fotonik, Denmark; Francesco Pavone, Instituto Nazionale di Ottica, Italy; Darcy Peterka, Columbia University, USA; Matthew Roos, Johns Hopkins University Applied Physics Laboratory, USA; Peter Saggau, Baylor College of Medicine, USA; Shy Shoham, Technion, Israel; Daniel Smalley, MIT, USA; Harbaljit Sohal, MIT Media Lab, USA; Lei Tian, University of California, Berkley, USA; Joshua Trachtenberg, UCLA, USA; Sanjay Varma, Johns Hopkins University Applied Physics Laboratory, USA; Alipasha Vaziri, University of Vienna (MFPL), Austria; Laura Waller, University of California, Berkley, USA; Ru Wang, MIT, USA; Chris Xu, Cornell, USA; Anthony Nicholas Zorzos, Massachusetts Institute of Technology, USA
Interested in Attending?
This meeting is by invitation only but a limited number of spots have been set aside for interested individuals. Please send a brief letter of interest along with a CV to the meeting hosts at OptogeneticsIncubator@osa.org.
The Spatially Precise Optogenetics at Depth Incubator Meeting will be taking place at OSA Headquarters in Washington, DC. OSA is located at 2010 Massachusetts Avenue, NW, Washington, DC. The meeting will take place in OSA’s P Street Conference Room, located on the 1st floor.
All attendees will be staying at the Hotel Palomar unless they have indicated otherwise to meeting management. The Hotel Palomar is located approximately one block from OSA’s headquarters in DuPont Circle.
OSA will manage your hotel reservations and book your room according to the arrival and departure information you provide on the registration form. Your sleeping room and relevant taxes will be charged to OSA for up to two nights. Should you choose to stay for more than two nights; you will be responsible for each additional night. Please email firstname.lastname@example.org with your name and the name of the incubator meeting for sleeping room rate and if you have any changes to your hotel dates as you submitted them on your RSVP.
This page will provide you with information on receiving a letter of invitation if required for your visa as well as additional logistical and area information.