Entry By:


Nanolive SA, Switzerland


Describe the profound impact your technology – as part of an end-user product – has had on Society. How has the population been impacted by your technology. This could be behavioral, economical, societal, etc.
Nanolive has developed a revolutionary microscope, the 3D Cell Explorer, which allows for the very first time the exploration of a living cell in 3D without damaging it. The 3D Cell Explorer displays the cell in a completely new way with a comprehensive representation of its morphology. It is based on an enabling technology that overcomes the limitation of light. Similar to a MRI scan for the human body, our product makes a complete tomography of the refractive index within the living cell. For the first time we can actually look inside the cell and study its interior organelles. Never again researchers will have to guess what happens inside a living cell. They will actually see and measure the impact of stimuli and drugs on cells, enabling completely new fields of research and smarter products. Since the cell is the basis of all life, this is a major milestone in the history of microscopy, which may change all the rules in the fields of Education, Bio, Pharma and Cosmetics Industry.
 
Tell us about how your technology is unique? What makes it stand out? How do you differentiate it from other similar technologies?
Since the discovery of the cell as the basic unit of life in the 17th century, scientists all around the world have been trying to investigate it deeper. They had to face two major obstacles: the cell’s very small dimensions (10-6 meters) and its transparency. The only way to circumvent these issues was to increase the complexity of the optics in order to gain resolution and to add color to the cell by adding chemical reagent or modifying it genetically.  This was still the case until today, even with the latest Nobel Prize technologies: the 2014 Nobel Prize for chemistry was assigned three scientists who made revolutionary discoveries in high resolution fluorescent microscopy. Nanolive completely opposes this trend andthe 3D Cell Explorer offers unperturbed and earlier unmet insights into the living cell: no need for any complex and long preparation. The observation is completely non-invasive to the cell, and allows resolving the cell’s parts down to 200nm.
 
When first launched, did your technology make a transformational change for the end-user or was it an advancement of the prior art? Describe this.
The 3D Cell Explorer is a tool for discovery and we are just at the beginning of exploring all the potential fields of research. It allows the measurement of cellular processes and kinetics in real-time enabling multi parameter analysis at single-cell and sub-cellular scale. Some of the fields of applications for our technology include: cell cycle monitoring, cell division and cell death analysis, cell-cell interactions, nanoparticles internalization, trafficking, cell motility monitoring, histopathology and many others. The company already obtained more than fifty pre-orders and the first products were delivered few months ago. The official market launch will take place during ASCB2015 in San Diego in December.
 
Give a specific example of the buying chain for your product/technology once you sell it to the next level buyer. Provide an example of the succession of companies your product goes through, ultimately to get to an end-user.
Nanolive sells mainly to end-users directly through its online shop: http://nanolive.ch/product/3d-cellexplorer/.
End-users are research labs in university (i.e. Harvard Medical School), Pharma, Biotech, Cosmetic companies, Hospitals but also Schools. For some specific countries we are also establishing distribution channels (i.e. Japan, Australia, Korea, …)
 
In which vertical market(s) would you classify the end-users of this technology?
Bio
 
Give us your one sentence “elevator pitch” you would use to tell a non-technical person about your technology and the critical role it plays in Society.
The 3D Cell Explorer is a revolutionary microscope able to image living cells instantly and in 3D without any stain or sample preparation. Scientists will finally be able to see and measure precisely the impact of stimuli and drugs on cells, thus enabling the creation of smarter products.
 
Surprise Us! What else should we know about your product/technology?
Our goal is to give every biologist, physician, scholar and student in labs, schools and universities all over the world the chance to explore and interact directly with living cells. 

Thanks to a few ground-breaking innovations, which simplify but also improve our technology, we are now capable of offering our 3D Cell Explorer at a surprisingly competitive price: 19’900 Euro.

That makes the 3D Cell Explorer, truly a discovery tool for everyone

Additional Information