A variety of techniques are being applied to in vivo optical imaging and spectroscopy in the case where the light is scattered many times as it passes through the sample. This group focuses on the use light to form images of tissue using diffusely scattered light or to determine tissue properties through spectroscopic measurements. Optical techniques used for both imaging and spectroscopy include reflection, absorption, fluorescence, phosphorescence, Raman, and the photo-acoustic effect. Such techniques are an essential tool for biomedical research involving small animals and hold great promise for clinical tasks such as breast cancer imaging, brain mapping, endoscopic imaging, and real-time feedback on efficacy during therapeutic procedures.
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