Powerful Imaging for Point-of-care Diagnostics

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Lyndsay Meyer
The Optical Society
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Powerful Imaging for Point-of-care Diagnostics

Researchers develop a handheld probe that can produce detailed images of blood vessels and other internal body parts without bulky, expensive instruments

Photoacoustic/ultrasound images taken with the new system show a human finger joint from different angles. The images on the right (b and d) show anatomical structures revealed by the ultrasound. The images on the left (a and c) show the photoacoutics data overlaying the ultrasound data. The bright yellow and red at the top of the finger show the skin and blood vessels running parallel to the finger. Credit: Pim van den Berg/ Khalid Daoudi 
Photoacoustic/ultrasound images taken with the new system show a human finger joint from different angles. The images on the right (b and d) show anatomical structures revealed by the ultrasound. The images on the left (a and c) show the photoacoustics data overlaying the ultrasound data. The bright yellow and red at the top of the finger show the skin and blood vessels running parallel to the finger. Credit: Pim van den Berg/ Khalid Daoudi

WASHINGTON, Nov. 5, 2014—A new handheld probe developed by a team of university and industry researchers in the Netherlands and France could give doctors powerful new imaging capabilities right in the palms of their hands. The imaging system, which is described in a paper published in The Optical Society’s (OSA) open-access journal Optics Express, shrinks a technology that once filled a whole lab bench down to a computer screen and a small probe about the size of a stapler.
 
The new device combines two imaging modalities: ultrasound and photoacoustics. Ultrasound is a well-established technology that analyzes how sound pulses echo off internal body parts. It is good at revealing anatomical structures and is, perhaps most familiarly, used to image a developing fetus in a mother's womb.
 
Photoacoustics is a relatively new imaging technique, still making its way toward widespread clinical applications. In photoacoustic imaging, short pulses of light heat up internal tissue. The slight temperature change leads to a change in pressure,
The new imaging system consists of a handheld probe (on the right), and an ultrasound scanning display system (on the left). It can be easily transported between rooms in a clinic. Credit: Pim van den Berg/ Khalid Daoudi
The new imaging system consists of a handheld probe (on the right), and an ultrasound scanning display system (on the left). It can be easily transported between rooms in a clinic. Credit: Pim van den Berg/ Khalid Daoudi

which in turn produces a wave of ultrasound that can be analyzed to reveal information about the body’s internal workings. Since this technique ultimately produces ultrasound waves as well, existing technology can be used to analyze and display the images.
 
The advantage of photoacoustics is that it can reveal important medical information that other imaging techniques cannot, including the presence of molecules like hemoglobin and melanin and the sub-millimeter structure of networks of blood vessels several centimeters beneath the skin. When combined with spectroscopic measurements, photoacoustics can also quantify hemoglobin oxygen saturation within single vessels, providing metabolic information that could be helpful for monitoring tumor progression, for example.
 
Yet despite these benefits, the cost and size of most photoacoustic systems limit their widespread use, said Khalid Daoudi, a researcher in the Biomedical Photonic Imaging Group at the University of Twente in the Netherlands. Most systems on the market require costly and bulky lasers that make the systems impractical for point-of-care diagnostics. “Our research aimed to break through these hindering factors,” Daoudi said.
 
The project started as collaboration between the University of Twente and three European companies: ESAOTE Europe, a maker of medical diagnostic systems, Quantel, a maker of solid state lasers, and SILIOS Technologies, a maker of optical components.
 
The team’s key innovation, which allowed them to dramatically shrink the system, was the design of an ultra-compact laser based on an efficient and inexpensive laser diode.  By stacking multiple diodes to increase the power and carefully designing optical elements to shape the laser beam, the team was able to generate laser pulses with energies higher than had ever been achieved before with diode technology.
 
Diode lasers can also provide many laser pulses per second, which in turn allows real time imaging, another advantage of the new system, Daoudi noted.
 
The researchers tested the imaging performance of the system in different types of phantoms—materials designed to mimic a tissue’s optical properties—and in a healthy human finger joint.
 
The new compact probe and imaging system can be easily transported between rooms in a clinical setting, an attractive feature for future commercialization, the researchers said.
 
The team is currently working with a European consortium of industrial and academic partners to take the next steps from the research to the commercialization phase. The current system operates at a single wavelength in the near infrared, but the team has plans to expand the design to multi-wavelength imaging.
 
“Some applications targeted are rheumatoid arthritis in finger joints, oncology, cardiovascular disease and burn wounds,” Daoudi said.
 
 Paper: "Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging," K. Daoudi et al., Optics Express, Vol. 22, Issue 21, pp. 26365-26374 (2014).
 
About Optics Express
Optics Express reports on new developments in all fields of optical science and technology every two weeks. The journal provides rapid publication of original, peer-reviewed papers. It is published by The Optical Society and edited by Andrew M. Weiner of Purdue University. Optics Express is an open-access journal and is available at no cost to readers online at www.OpticsInfoBase.org/OE.
 
About OSA
Founded in 1916, The Optical Society (OSA) is the leading professional organization for scientists, engineers, students and entrepreneurs who fuel discoveries, shape real-life applications and accelerate achievements in the science of light. Through world-renowned publications, meetings and membership initiatives, OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of optics and photonics experts. OSA is a founding partner of the National Photonics Initiative and the 2015 International Year of Light. For more information, visit www.osa.org.